Sharbeen cancer research slc7a11
WebbGeorge Sharbeen Joshua A Mccarroll Anouschka Akerman [...] Phoebe A Phillips Cancer-associated fibroblasts (CAF) are major contributors to pancreatic ductal adenocarcinoma (PDAC) progression... Webb13 maj 2024 · "We found that switching off SLC7A11 in mice with pancreatic tumors directly killed pancreatic cancer cells, reduced the spread of tumor cells throughout their body and decreased the scar...
Sharbeen cancer research slc7a11
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Webb18 apr. 2024 · Indeed, overexpression of xCT has been reported in nonsmall cell lung cancer, breast cancer, and liver cancer and is associated with poor outcomes (18–21). Furthermore, xCT has been implicated in promoting tumorigenesis through its antioxidant function, which supports breast cancer cell proliferation ( 19 ), matrix invasion of glioma … WebbCancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition George Sharbeen et al, 2024, Cancer Research CrossRef; The …
Webb13 maj 2024 · SLC7A11 has been studied in pancreatic cancer cells before, but this is the first piece of research to show that it plays a critical role in non-tumour helper cells, too. … Webb23 maj 2024 · Diverse regulatory mechanisms of SLC7A11 in cancer are summarized, ferroptosis-dependent and -independent functions of S LC7A 11 in promoting tumor development are discussed, the mechanistic basis of SLP11-induced nutrient dependency in cancer cells is explored, and therapeutic strategies to target SLC 7A11 are …
WebbThe vulnerability of ARID1A-deficient cancer cells results from low basal levels of GSH due to impaired expression of SLC7A11. The SLC7A11 -encoded cystine transporter supplies cells with cysteine, a key source of GSH, and its expression is enhanced by ARID1A-mediated chromatin remodeling. Thus, ARID1A-deficient cancers are susceptible to ... Webb17 dec. 2024 · Importantly, the expression of SLC7A11 mRNA was strictly restricted to the tumor cells themselves, as was determined using single cell-RNAseq data retrieved from …
Webb29 apr. 2024 · CAL is an inventor on patents pertaining to Kras-regulated metabolic pathways, redox control pathways in pancreatic cancer, and targeting GOT1 as a therapeutic approach (Methods for diagnosing and treating oncogenic Kras-associated cancer, US patent no. 2015126580-A1; Targeting the glutamine to pyruvate pathway for …
WebbArticles by George Sharbeen on Muck Rack. Find George Sharbeen's email address, contact information, LinkedIn, ... Cancer Research. Metabolism and Chemical Biology … how to hook mouse tailsWebbSLC7A11 / XCT is a member of a heteromeric, sodium-independent, ... Koglin N, Hultsch C, Schatz CA, Dinkelborg LM, Mittra ES, Gambhir SS, Moon DH. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 18:5427-37. (IHC; Human) [PubMed:22893629] ... how to hook my hp printer to wifiWebbLowy Cancer Research Centre; George Sharbeen; ... CAF inhibition is thus an ideal component of any therapeutic approach for PDAC. SLC7A11 is a cystine transporter that … how to hook multiple screens to laptopWebb28 juni 2024 · Cancer therapy has evolved beyond solely targeting cancer cells and now considers the tumor microenvironment (TME) as well. The cellular and acellular … how to hook my computer to tvWebbSharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; ... Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2024, Data from Cancer … how to hook my firestick to my laptopWebb13 maj 2024 · More information: George Sharbeen et al. Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition, Cancer … how to hook minnowsWebb22 aug. 2024 · Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, et al. Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic … joint of pork