Chemodynamictherapy
WebApr 13, 2024 · Nanoenzymes have been widely explored for chemodynamic therapy (CDT) in cancer treatment. However, poor catalytic efficiency of nanoenzymes, especially in the tumor microenvironment with insufficient H 2 O 2 and mild acidity, limits the effect of CDT. Herein, we developed a new ultrathin RuCu nanosheet (NS) based nanoenzyme … WebDec 1, 2024 · Abstract. Chemodynamic therapy (CDT) destroys cancer cells by converting H 2 O 2 or O 2 into reactive oxygen species (ROS), but its therapeutic efficacy is restricted …
Chemodynamictherapy
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WebApr 6, 2024 · Chemodynamic therapy CDT is a form of in situ treatment that uses the Fenton reaction or Fenton-like reactions to generate ·OH radicals at tumor sites. 111 Essentially, iron-based nanomaterials dissolve in the weakly acidic conditions of the TME to generate iron ions and initiate the Fenton reaction, which produce excess hydrogen … WebNov 1, 2024 · Chemodynamic therapy (CDT) can efficiently destroy tumor cells via Fenton reaction in the presence of H2O2 and a robust catalyst. However, it has faced severe challenges including the limited amounts of H2O2 and inefficiency of catalysts. Here, an adenosine triphosphate (ATP)-responsive autocatalytic Fenton nanosystem …
WebOct 28, 2024 · Chemodynamic therapy (CDT), a newly developed approach for cancer treatment, can convert hydrogen peroxide (H2O2) into toxic hydroxyl radicals (•OH) by using Fenton/Fenton-like reaction to kill tumor cells. However, due to the complexity of the intracellular environment of tumor cells, the therapeutic efficacy of CDT was severely … WebChemodynamic therapy (CDT) that utilizes Fenton-type reactions to convert endogenous hydrogen peroxide (H 2 O 2) into hydroxyl radicals (• OH) is a promising strategy in anticancer treatment, but the overexpression of glutathione (GSH) and limited endogenous H 2 O 2 make the efficiency of CDT unsatisfactory. Here, an intelligent nanoplatform …
WebApr 11, 2024 · Chemodynamic therapy (CDT) driven by Fenton/Fenton-like reaction is known as a potential tumor therapeutic modality with minimal side effects [1, 2].Generally, nano-catalysts and H 2 O 2 are the two key initiators and limitation factors of CDT [3, 4].Benefiting from the high catalytic activity, iron (Fe)-based nanoparticles have been … WebDec 22, 2024 · Integrating chemodynamic therapy (CDT) and photodynamic therapy (PDT) into one nanoplatform can produce much more reactive oxygen species (ROS) for tumor therapy. Nevertheless, it is still a great challenge to selectively generate sufficient ROS in tumor regions. Meanwhile, CDT and PDT are restricted by insufficient H2O2 …
WebFeb 6, 2024 · CDT, chemodynamic therapy; PDT, photodynamic therapy; PTT, photothermal therapy. IMMUNOTHERAPY APPLICATIONS OF CDs Synergistic PDT. PDT has been studied as an immunogenic cell death (ICD) inducer for eliciting direct tumor-killing effects through the creation of tumor antigen pools with danger signals that promote …
WebNov 13, 2024 · [email protected]/MnO incubation showed higher cytotoxicity to C6 glioma cells compared to that observed with [email protected] incubation, suggesting a synergistic therapeutic effect of chemotherapy and chemodynamic therapy (CDT). Quantitative assessment of C6 glioma cell apoptosis using flow cytometry yielded consistent results. index ingWebDec 1, 2024 · Chemodynamic therapy (CDT) is an emerging cancer treatment strategy that uses CDT agents to convert hydrogen peroxide (H 2 O 2) into the hydroxyl radical (OH), … indexing a 2d array pythonWebApr 10, 2024 · The multifunctional platform response to the tumor microenvironment (TME) is critical for the high-precision diagnosis and treatment of cancer with low systemic toxicity. In this regard, vanadium-doped carbon dots (V−CDs) have been developed for TME-activated fluorescence imaging and chemodynamic therapy (CDT). Due to the Forster … index informatikWebJun 28, 2024 · Chemodynamic therapy (CDT), which is defined as in-situ treatment via Fenton and Fenton-like reactions, has attracted more and more attention in recent … indexing4u waitrose.comWebThe enriched intracellular Cu(II) ions could induce the oligomerization of lipoylated proteins and proteotoxic stress for cuproptosis, and lipid peroxidation for chemodynamic therapy as well. Moreover, the CSTD-Cu(II)@DSF could cause the dysfunction of mitochondria and arrest the cell cycle at the G2/M phase, leading to enhanced DSF-mediated ... index ing01WebMar 26, 2024 · In the past five years, the authors and others have demonstrated that numerous nanomedicines, by simultaneously delivering GSH-depleting agents and therapeutic components, boost not only traditional chemotherapy and radiotherapy but also multifarious emerging treatment modalities, including photodynamic therapy, … indexing a cell arrayWebNov 29, 2024 · Abstract. Applying Fenton chemistry in the tumor microenvironment (TME) for cancer therapy is the most significant feature of chemodynamic therapy (CDT). … index ing 2014